Thionyl Chloride → Hydrochloric Acid

HRID 630020Notes

Reaction equation

HRID 630020 reaction equation
[Cl:1][C:2]1[N:3]([CH2:11]O)[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.O=S(Cl)[Cl:15]>>[Cl:1][C:2]1[N:3]([CH2:11][Cl:15])[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.[ClH:1]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 59589510(3-chloro-2H-indazol-2-yl)methanol

Product 2

HCID 313Hydrochloric AcidHCID 595894213-chloro-2-(chloromethyl)-2H-indazole

Procedure

(3-chloro-2H-indazol-2-yl)methanol was dissolved in SOCl2 (10 mL). The mixture was stirred at room temperature for 3 hours and evaporated to provide crude 3-chloro-2-(chloromethyl)-2H-indazole as a HCl salt.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-a7f5b2af01a0474496db2c712f00a9b2
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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