HCID 22558806, compound → 3-[3-Fluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid

HRID 63005Notes

Reaction equation

HRID 63005 reaction equation
Cl[CH2:2][C:3]1[C:4]([S:9][CH2:10][CH2:11][CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1.C[O:14][C:15](=[O:26])[CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([F:25])[CH:19]=1>>[F:25][C:20]1[CH:19]=[C:18]([CH2:17][CH2:16][C:15]([OH:26])=[O:14])[CH:23]=[CH:22][C:21]=1[O:24][CH2:2][C:3]1[C:4]([S:9][CH2:10][CH2:11][CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 22558806HCID 22558806, compoundHCID 901182823-Chloromethyl-2-propylsulfanyl-pyridine

Product 1

HCID 901183123-[3-Fluoro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acidYield 73%

Procedure

3-Chloromethyl-2-propylsulfanyl-pyridine (0.030 g, 0.15 mmol) obtained in Step C of Preparation Example 14 and 3-(3-fluoro-4-hydroxy-phenyl)-propionic acid methyl ester (0.031 g, 0.15 mmol) obtained in Step C of Preparation Example 6 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.038 g, 73%).

Workup

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Sources & evidence

ORD record
ord-db553c0fd7c24bf1a09305fe26841a30
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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