Phosphorus tribromide → HCID 13593314, compound

HRID 630057Notes

Reaction equation

HRID 630057 reaction equation
[Cl:1][C:2]1[C:11]([CH2:12]O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.P(Br)(Br)[Br:15]>C(Cl)(Cl)Cl>[Br:15][CH2:12][C:11]1[C:2]([Cl:1])=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 930708(2-chloroquinolin-3-yl)methanol

Product 1

HCID 13593314HCID 13593314, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of (2-chloroquinolin-3-yl)methanol (0.96 g, 4.95 mmol) in anhydrous chloroform at 0° C. was added phosphorous tribromide (1.34 g, 4.95 mmol). After stirring at room temperature for 2 hours, the solvent was evaporated to provide 3-(bromomethyl)-2-chloroquinoline (1.27 g), which was used in the next step without purification.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-356086991f9c4f0986736fe32296d08a
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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