HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → HCID 13593314, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (2-Chloroquinolin-3-yl)methanol | HCID 930708 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 13593314 | HCID 13593314 | 100% |
Reaction Steps
To a solution of (2-chloroquinolin-3-yl)methanol (0.96 g, 4.95 mmol) in anhydrous chloroform at 0° C. was added phosphorous tribromide (1.34 g, 4.95 mmol). After stirring at room temperature for 2 hours, the solvent was evaporated to provide 3-(bromomethyl)-2-chloroquinoline (1.27 g), which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315521B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-356086991f9c4f0986736fe32296d08a |
| Source note | uspto-grants-2016_04 |