Ethyl 3-(3-fluoro-4-hydroxyphenyl)propionate → HCID 74221851, compound

HRID 63010Notes

Reaction equation

HRID 63010 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]([CH3:12])[CH3:11])[N:4]=1.C([O:15][C:16](=[O:27])[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([F:26])[CH:20]=1)C>>[F:26][C:21]1[CH:20]=[C:19]([CH2:18][CH2:17][C:16]([OH:27])=[O:15])[CH:24]=[CH:23][C:22]=1[O:25][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([S:9][CH:10]([CH3:12])[CH3:11])[N:4]=1

Participants

3

Reactant 2

HCID 3023769Ethyl 3-(3-fluoro-4-hydroxyphenyl)propionateHCID 901181412-Chloromethyl-6-isopropylsulfanyl-pyridine

Product 1

HCID 74221851HCID 74221851, compoundYield 83.8%

Procedure

2-Chloromethyl-6-isopropylsulfanyl-pyridine (0.028 g, 0.14 mmol) obtained in Step C of Preparation Example 16 and 3-(3-fluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (0.030 g, 0.14 mmol) obtained in Step C of Preparation Example 6 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.041 g, 83%).

Workup

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Sources & evidence

ORD record
ord-1d18889fcc214a79a39908c269ff52e9
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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