Ethyl 3-(3-chloro-4-hydroxyphenyl)propanoate → HCID 90118052, compound

HRID 63015Notes

Reaction equation

HRID 63015 reaction equation
Cl[CH2:2][C:3]1[C:4]([S:9][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[N:5][CH:6]=[CH:7][CH:8]=1.C([O:16][C:17](=[O:28])[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[C:22]([Cl:27])[CH:21]=1)C>>[Cl:27][C:22]1[CH:21]=[C:20]([CH2:19][CH2:18][C:17]([OH:28])=[O:16])[CH:25]=[CH:24][C:23]=1[O:26][CH2:2][C:3]1[C:4]([S:9][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 68766162Ethyl 3-(3-chloro-4-hydroxyphenyl)propanoateHCID 901181843-Chloromethyl-2-cyclopropylmethylsulfanyl-pyridine

Product 1

HCID 90118052HCID 90118052, compoundYield 74%

Procedure

3-Chloromethyl-2-cyclopropylmethylsulfanyl-pyridine (35 mg, 0.16 mmol) obtained in Step C of Preparation Example 18 and 3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester (42 mg, 0.18 mmol) obtained in Step C of Preparation Example 42 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (38 mg, 74%).

Workup

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Sources & evidence

ORD record
ord-c17ee2365f08409cb09ca861e0cdf132
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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