Ethyl 3-(3-chloro-4-hydroxyphenyl)propanoate → 3-[3-Chloro-4-(2-cyclopropylmethylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-propionic acid

Participants

Reaction Steps

3-Chloromethyl-2-cyclopropylmethylsulfanyl-pyridine (35 mg, 0.16 mmol) obtained in Step C of Preparation Example 18 and 3-(3-chloro-4-hydroxy-phenyl)-propionic acid ethyl ester (42 mg, 0.18 mmol) obtained in Step C of Preparation Example 42 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (38 mg, 74%).

Provenance & Evidence