反应详情

Lithium aluminum hydride (234 mg, 6.2 mmol) was stirred in anhydrous THF (30 mL) A solution of ethyl 4-chloro-2-ethylpyridine-3-carboxylate (878 mg, 4.1 mmol) in anhydrous THF (5 mL) was added at 0° C., and the reaction mixture was stirred at room temperature for 1.5 hours. The reaction was quenched with an aqueous solution of sodium hydroxide and extracted 5 times with ethyl acetate. The combined organic phase was washed with brine and dried over sodium sulfate. After evaporation of the solvent, (4-chloro-2-ethylpyridin-3-yl)methanol was obtained as an oil (601 mg, 85% yield) and used in the next step without further purification.

1. additionwas added at 0° C.
2. customThe reaction was quenched with an aqueous solution of sodium hydroxide
3. extractionextracted 5 times with ethyl acetate
4. washThe combined organic phase was washed with brine
5. dry with materialdried over sodium sulfate
6. customAfter evaporation of the solvent