反应详情

To the suspension of LAH (0.95 g, 25 mmol) in THF (100 mL), ethyl 2,4-dimethylpyridine-3-carboxylate (1.5 g, 8.4 mmol) was added dropwise as a solution in THF (10 mL) at 0° C. After 30 minutes, the reaction was quenched by addition of acetone/water and then more water (100 mL) was added. The mixture was extracted with DCM (3×100 mL), dried over magnesium sulfate, and evaporated to provide (2,4-dimethylpyridin-3-yl)methanol, which was used in the next step without any further purification.

1. customthe reaction was quenched by addition of acetone/water
2. additionmore water (100 mL) was added
3. extractionThe mixture was extracted with DCM (3×100 mL)
4. dry with materialdried over magnesium sulfate
5. customevaporated