Hydrochloric Acid → HCID 68489054, compound

HRID 630328Notes

Reaction equation

HRID 630328 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]([CH2:14][CH:15]2[CH2:19][CH2:18][CH2:17][N:16]2C(OC(C)(C)C)=O)[CH3:13])=[CH:7][CH:6]=1)=[O:4].Cl>ClCCl>[CH3:13][N:12]([CH2:11][C:8]1[CH:7]=[CH:6][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:10][CH:9]=1)[CH2:14][CH:15]1[CH2:19][CH2:18][CH2:17][NH:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 684847491,1-Dimethylethyl 2-[[[[4-(methoxycarbonyl)phenyl]methyl]methylamino]methyl]-1-pyrrolidinecarboxylate

Product 1

HCID 68489054HCID 68489054, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1,1-dimethylethyl 2-[[[[4-(methoxycarbonyl)phenyl]methyl]methylamino]methyl]-1-pyrrolidinecarboxylate in dichloromethane was treated with 4 N HCl (2 mL) and stirred at ambient temperature for 4 hours. The reaction was concentrated to give methyl 4-[[methyl(2-pyrrolidinylmethyl)amino]methyl]benzoate as a hydrochloride salt.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-9f71a68d61094ee9b6b538de8d2bd564
Source dataset
uspto-grants-2016_04
Patent number
US09315509B2

Reaction notes

Loading…