HRID630392

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CC(=O)Nc1ccc(CO[Si](C)(C)C(C)(C)C)cc1Cl

HCID67145162

未命名化合物

2 次

结构：CN[C@H]1CC[C@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1

HCID178484861

未命名化合物

2 次

结构：COc1cc(NC(=O)CCN(C)[C@H]2CC[C@H](OC(=O)C(O)(c3cccs3)c3cccs3)CC2)c(Cl)cc1CO[Si](C)(C)C(C)(C)C

HCID178493273

未命名化合物

PRODUCTS

生成物

结构：CN(CCC(=O)Nc1ccc(CO[Si](C)(C)C(C)(C)C)cc1Cl)[C@H]1CC[C@H](OC(=O)C(O)(c2cccs2)c2cccs2)CC1

HCID178483940

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Obtained as a beige solid (45%) starting from N-[4-({[tert-butyl(dimethyl)silyl]oxy}-methyl)-2-chlorophenyl]-acrylamide (intermediate 47; 0.56 g, 1.73 mmol) and trans-4-(methylamino)cyclohexyl hydroxy(di-2-thienyl)acetate (intermediate 5; 0.5 g, 1.42 mmol) in 14 ml dichloromethane and following the experimental procedure as described for intermediate 41.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de4de64076c742c1ac2df0f17b050acc
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09315463B2
来源说明: uspto-grants-2016_04

反应 SMILES

[Si](OCC1C=CC(NC(=O)C=C)=C(Cl)C=1)(C(C)(C)C)(C)C.OC(C1SC=CC=1)(C1SC=CC=1)C(O[C@H]1CC[C@H](NC)CC1)=O.[OH:45][C:46]([C:86]1[S:87][CH:88]=[CH:89][CH:90]=1)([C:81]1[S:82][CH:83]=[CH:84][CH:85]=1)[C:47]([O:49][C@H:50]1[CH2:55][CH2:54][C@H:53]([N:56]([CH2:58][CH2:59][C:60]([NH:62][C:63]2[CH:68]=[C:67](OC)[C:66]([CH2:71][O:72][Si:73]([C:76]([CH3:79])([CH3:78])[CH3:77])([CH3:75])[CH3:74])=[CH:65][C:64]=2[Cl:80])=[O:61])[CH3:57])[CH2:52][CH2:51]1)=[O:48]>ClCCl>[OH:45][C:46]([C:81]1[S:82][CH:83]=[CH:84][CH:85]=1)([C:86]1[S:87][CH:88]=[CH:89][CH:90]=1)[C:47]([O:49][C@H:50]1[CH2:51][CH2:52][C@H:53]([N:56]([CH2:58][CH2:59][C:60]([NH:62][C:63]2[CH:68]=[CH:67][C:66]([CH2:71][O:72][Si:73]([C:76]([CH3:79])([CH3:78])[CH3:77])([CH3:75])[CH3:74])=[CH:65][C:64]=2[Cl:80])=[O:61])[CH3:57])[CH2:54][CH2:55]1)=[O:48]