Piperazin-2-one → HCID 118666134, compound

HRID 630473Notes

Reaction equation

HRID 630473 reaction equation
[CH3:1][S:2]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13](O)=[O:14])=[CH:10][CH:11]=2)[N:6]([C:16]2[N:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:18][N:17]=2)[CH:5]=1)=[O:3].[NH:28]1[CH2:33][CH2:32][NH:31][CH2:30][C:29]1=[O:34]>>[CH3:1][S:2]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([N:31]3[CH2:32][CH2:33][NH:28][C:29](=[O:34])[CH2:30]3)=[O:14])=[CH:10][CH:11]=2)[N:6]([C:16]2[N:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:18][N:17]=2)[CH:5]=1)=[O:3]

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 118666144HCID 118666144, compound

Product 1

HCID 118666134HCID 118666134, compound

Procedure

Synthesized from 3-(methylsulfinyl)-1-(5-phenylpyrimidin-2-yl)-1H-indole-6-carboxylic acid (200 mg, 0.53 mmol) and piperazin-2-one (64 mg, 0.63 mmol) in an analogous manner as described for example 52. White solid. Yield: 148 mg (61% of theory). HPLC-MS (method 4): Rt=2.6 min; m/z [M+H]+=460.3

Sources & evidence

ORD record
ord-5b56d02b4a6241f8a13528c11e0100b7
Source dataset
uspto-grants-2016_04
Patent number
US09315490B2

Reaction notes

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