HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → HCID 118666094, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Potassium trimethylsilanolate | HCID 23668039 | — |
| Reactant | HCID 118676805 | HCID 118676805 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 118666094 | HCID 118666094 | — |
Reaction Steps
Prepared from methyl 3-(2-(3-(methylthio)-6-(morpholine-4-carbonyl)-1H-indol-1-yl)pyrimidin-5-yl)benzoate (precursor of example 192) in two reaction steps comprising an ester hydrolysis with potassium trimethylsilanolate in THF and water and an oxidation of the thioether with hydrogen peroxide in acetic acid. White solid. Yield: 90 mg. Melting range: 230-235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315490B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a6a92645930d48558b9cd8da44975a37 |
| Source note | uspto-grants-2016_04 |