2-Fluoro-5-methoxyphenylboronic acid → HCID 118666086, compound

HRID 630514Notes

Reaction equation

HRID 630514 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([N:19]([CH3:21])[CH3:20])=[O:18])[CH:15]=3)[C:10]([S:22]([CH3:24])=[O:23])=[CH:9]2)=[N:6][CH:7]=1.[F:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1B(O)O>>[F:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1[C:2]1[CH:3]=[N:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([N:19]([CH3:21])[CH3:20])=[O:18])[CH:15]=3)[C:10]([S:22]([CH3:24])=[O:23])=[CH:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 41572112-Fluoro-5-methoxyphenylboronic acidHCID 118666104HCID 118666104, compound

Product 1

HCID 118666086HCID 118666086, compound

Procedure

Suzuki reaction of 1-(5-bromopyrimidin-2-yl)-N,N-dimethyl-3-(methylsulfinyl)-1H-indole-6-carboxamide (0.15 g, 0.37 mmol; intermediate in the preparation of synthesis example 267) with 2-fluoro-5-methoxyphenylboronic acid (0.13 g, 0.74 mmol) in analogy to the procedure detailed for example 261). White solid. Yield: 0.06 g (36% of theory)

Sources & evidence

ORD record
ord-554818f2433c4f8490c37d743daa5bc3
Source dataset
uspto-grants-2016_04
Patent number
US09315490B2

Reaction notes

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