2-chloro-4-cyclopropylpyridine → HCID 118676831, compound

HRID 630544Notes

Reaction equation

HRID 630544 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19][CH3:20])=[O:18])[CH:15]=3)[C:10]([S:21][CH3:22])=[CH:9]2)=[N:6][CH:7]=1.Cl[C:24]1[CH:29]=[C:28]([CH:30]2[CH2:32][CH2:31]2)[CH:27]=[CH:26][N:25]=1>>[CH:30]1([C:28]2[CH:27]=[CH:26][N:25]=[C:24]([C:2]3[CH:3]=[N:4][C:5]([N:8]4[C:16]5[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19][CH3:20])=[O:18])[CH:15]=5)[C:10]([S:21][CH3:22])=[CH:9]4)=[N:6][CH:7]=3)[CH:29]=2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 457879142-chloro-4-cyclopropylpyridineHCID 118666039Methyl 1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indole-6-carboxylate

Product 1

HCID 118676831HCID 118676831, compound

Procedure

Synthesized from methyl 1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indole-6-carboxylate (1.7 g, 4.49 mmol) and 2-chloro-4-cyclopropylpyridine (1.03 g, 6.73 mmol) in analogy to the procedures 141a) and b). White solid. Yield: 1.2 g (64% of theory)

Sources & evidence

ORD record
ord-8ecb973843e444ca9e12cf92663a40a3
Source dataset
uspto-grants-2016_04
Patent number
US09315490B2

Reaction notes

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