Diisopropylethylamine → 6-Amino-N-[(2R)-1-amino-1-oxo-3-(tritylsulfanyl)propan-2-yl]hexanamide

Participants

Reaction Steps

678 mg (0.97 mmol) of the compound of example 20A was dissolved in 7 ml dimethyl formamide and 0.19 ml (1.94 mmol) DIEA was added. After one hour reaction time, the raw product was purified by preparative RP-HPLC on a C18 column with a water methanol gradient from 9/1 to 1/9. The product-containing fractions were combined and concentrated to dryness under reduced pressure. This gave 457 mg (0.93 mmol, 95% of theory) of the desired product.

Provenance & Evidence