反应详情

678 mg (0.97 mmol) of the compound of example 20A was dissolved in 7 ml dimethyl formamide and 0.19 ml (1.94 mmol) DIEA was added. After one hour reaction time, the raw product was purified by preparative RP-HPLC on a C18 column with a water methanol gradient from 9/1 to 1/9. The product-containing fractions were combined and concentrated to dryness under reduced pressure. This gave 457 mg (0.93 mmol, 95% of theory) of the desired product.

1. customAfter one hour reaction time
2. customthe raw product was purified by preparative RP-HPLC on a C18 column with a water methanol gradient from 9/1 to 1/9
3. concentrationconcentrated to dryness under reduced pressure