Acetic Acid → 4'-Bromochalcone

Participants

Reaction Steps

In a 500 mL flask, 99.4 g (0.50 mol) of 4-bromoacetophenone and 53.0 g (0.5 mol) of benzaldehyde were initially charged and dissolved in 50 g of methanol. The mixture was admixed with 6.7 g (0.025 mol) of 15% strength aqueous sodium hydroxide solution carefully added dropwise at 20-25° C. and subsequently stirred for 3 h. The reaction mixture was neutralized with glacial acetic acid and filtered and the solid was dried in vacuo to obtain 107 g (351 mmol) of (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one.

Provenance & Evidence