Acetic Acid → 4'-Bromochalcone

HRID 630686ノート

反応式

HRID 630686 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][CH:5]=1)=[O:3].[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[OH-].[Na+].C(O)(=O)C>CO>[Br:10][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])/[CH:1]=[CH:11]/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 240BenzaldehydeHCID 7466p-BromoacetophenoneHCID 14798Sodium Hydroxide

生成物 1

HCID 53552044'-Bromochalcone収率 70.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In a 500 mL flask, 99.4 g (0.50 mol) of 4-bromoacetophenone and 53.0 g (0.5 mol) of benzaldehyde were initially charged and dissolved in 50 g of methanol. The mixture was admixed with 6.7 g (0.025 mol) of 15% strength aqueous sodium hydroxide solution carefully added dropwise at 20-25° C. and subsequently stirred for 3 h. The reaction mixture was neutralized with glacial acetic acid and filtered and the solid was dried in vacuo to obtain 107 g (351 mmol) of (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one.

後処理

  1. additioncarefully added dropwise at 20-25° C.
  2. filtrationfiltered
  3. customthe solid was dried in vacuo

出典と根拠

ORDレコード
ord-f5c111831da94ecbb0058a4a70970e67
出典データセット
uspto-grants-2016_04
特許番号
US09317012B2

反応ノート

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