反应详情

Distilled water (3.0 mL) and 10% aqueous NaOH (1.5 mL) were added to compound 118E (300 mg, 0.78 mmol) and the mixture was heated under reflux for 2 h. The pH of the solution was then adjusted to 4.0 by addition of 1.0 M HCl, the resulting precipitate was isolated by filtration, washed with cold water, and dried to give 201 mg (0.64 mmol, 82%) of the product as a solid, mp 209-210° C.; 1H NMR (600 MHz, DMSO-d6) δ 3.59 (s, 2H), 6.52 (d, 2H, J=8.1 Hz), 7.42 (d, 2H, J=8.9 Hz); 13C NMR (75 MHz, DMSO-d6) δ 36.6, 113.3, 127.8, 128.4, 152.4, 153.3, 167.7, 170.4; MS (LCQ, ESI+) Calcd for C10H11N4O4S2 315.0. found 315.0 (M+H)+. HRMS (ESI+, m/z) Calcd for C10H11N4O4S2 315.0222. found 315.0220 (M+H)+.

1. distillationDistilled water (3.0 mL) and 10% aqueous NaOH (1.5 mL)
2. temperaturethe mixture was heated
3. temperatureunder reflux for 2 h
4. customthe resulting precipitate was isolated by filtration
5. washwashed with cold water
6. customdried