HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 631202Generated: October 29, 2026
5-Amino-2-chlorophenol → 1-(5-Tert-butylisoxazol-3-yl)-3-(4-chloro-3-hydroxyphenyl)urea
https://huagongshe.com/reaction/631202
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Amino-2-chlorophenol | HCID 80676 | — |
| Reactant | 5-Tert-butyl-3-isocyanato-1,2-oxazole | HCID 12918838 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(5-Tert-butylisoxazol-3-yl)-3-(4-chloro-3-hydroxyphenyl)urea | HCID 66877362 | — |
Reaction Steps
A mixture of 5-amino-2-chlorophenol (1.0 g, 6.97 mmol) and 5-tert-butyl-3isocyanatoisoxazole (1.16 g, 6.97 mmol) in toluene (40 mL) was heated at 70° C. overnight. It was purified by silica gel chromatography with 0-25% EtOAc/hexane as eluants to afford 1-(5-tert-butylisoxazol-3-yl)-3-(4-chloro-3-hydroxyphenyl)urea as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09320739B2 |
|---|
| Source dataset | uspto-grants-2016_04 |
|---|
| ORD ID | ord-eef3c935e5684fa39de67bb722a7a867 |
|---|
| Source note | uspto-grants-2016_04 |
|---|
