Phenylhydrazine → 3-Cyclobutyl-1-phenyl-1H-pyrazol-5-amine

HRID 631717Notes

Reaction equation

HRID 631717 reaction equation
[CH:1]1([C:5](=O)[CH2:6][C:7]#[N:8])[CH2:4][CH2:3][CH2:2]1.[C:10]1([NH:16][NH2:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(O)C>[CH:1]1([C:5]2[CH:6]=[C:7]([NH2:8])[N:16]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:17]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 7516PhenylhydrazineHCID 138611153-Cyclobutyl-3-oxopropanenitrile

Product 1

HCID 431589603-Cyclobutyl-1-phenyl-1H-pyrazol-5-amineYield 43%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A stirred mixture of 3-cyclobutyl-3-oxopropanenitrile (24.6 g, 0.20 mol) and phenylhydrazine (23.62 g, 0.20 mol) in ethanol (200 mL) was heated at 90° C. for 15 h. The reaction mixture was quenched with water and extracted with dichloromethane. The combined dichloromethane layers were dried over magnesium sulfate, concentrated under reduced pressure to give a solid which was triturated with a mixture of 10% petroleum ether in ethyl acetate, followed by trituration with diethyl ether to afford 3-cyclobutyl-1-phenyl-1H-pyrazol-5-amine (18.20 g, 43% over two steps) as a colorless solid. 1H NMR (400 MHz, DMSO-d6) δ7.55-7.57 (m, 2H), 7.42-7.46 (m, 2H), 7.26 (m, 1H), 5.40 (s, 1H), 5.25 (s, 2H), 3.33 (m, 1H), 2.05-2.50 (m, 4H), 1.82-1.96 (m, 2H).

Workup

  1. customThe reaction mixture was quenched with water
  2. extractionextracted with dichloromethane
  3. dry with materialThe combined dichloromethane layers were dried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customto give a solid which
  6. customwas triturated with a mixture of 10% petroleum ether in ethyl acetate

Sources & evidence

ORD record
ord-55ea4691a8e44f6bbf5dfeb529e8f608
Source dataset
uspto-grants-2016_04
Patent number
US09320739B2

Reaction notes

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