HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (E)-4,4-Difluoropent-2-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl (E)-4,4-difluoropent-2-enoate | HCID 118534660 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (E)-4,4-Difluoropent-2-enoic acid | HCID 75530053 | — |
Reaction Steps
The product of step C was dissolved in ethanol (24 ml), 4M NaOH was added (12 ml) and the mixture was stirred at room temperature for two hours. The mixture was acidified with 1M HCl and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate, the solvent was removed under reduced pressure. 2.67 g of a colourless oil were obtained. MS(ESI) m/z=135.0 [M-1]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321724B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d7cf04eecd664c3bae49e9772e35ce70 |
| Source note | uspto-grants-2016_04 |