Ethylenediamine → N1-(4-Methyl-1,3-thiazol-2-YL)ethane-1,2-diamine

Temperature

120 °C

A mixture of 2-bromo-4-methylthiazole (502 mg, 2.82 mmol), ethylenediamine (15 mL, 224 mmol) and potassium carbonate (780 mg, 5.64 mmol) was heated under microwave heating at 120° C. for 30 min in a closed vial. Ethanol (200 mL) was added, the resulting mixture was filtered, the solids washed with EtOH and the combined filtrates concentrated under reduced pressure. The residue was mixed with toluene and concentrated under reduced pressure; this step was repeated two times after which 620 mg of a solid was obtained that was used directly in the next step.

1. temperaturewas heated under microwave
2. filtrationthe resulting mixture was filtered
3. washthe solids washed with EtOH
4. concentrationthe combined filtrates concentrated under reduced pressure
5. additionThe residue was mixed with toluene
6. concentrationconcentrated under reduced pressure
7. customwas obtained

ORD record

ord-29cfbb88ca444912943bb3ceb6246bb8

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09321724B2