反应详情

tert-Butyl N-methyl-N-[2-[methyl-(5-methyl-3-pyridyl)amino]ethyl]carbamate (301 mg, 1.078 mmol) was dissolved in DCM (40 ml). Hydrochloric acid (4M in dioxane, 5.4 ml) was added and the mixture was stirred at room temperature for 48 hours. The mixture was concentrated under reduced pressure, diethylether was added and the mixture was stirred at room temperature for 4 days. The solids were collected by filtration, rinsed with diethylether and dried under reduced pressure to yield 199 mg (0.789 mmol, 73%) MS(ESI) m/z=180.2 [M+1]+.

1. concentrationThe mixture was concentrated under reduced pressure, diethylether
2. additionwas added
3. stirringthe mixture was stirred at room temperature for 4 days
4. filtrationThe solids were collected by filtration
5. washrinsed with diethylether
6. customdried under reduced pressure
7. customto yield 199 mg (0.789 mmol, 73%) MS(ESI) m/z=180.2 [M+1]+