Ethylenediamine → HCID 89825830, compound

HRID 631829Notes

Reaction equation

HRID 631829 reaction equation
Cl[C:2]1[N:6]=[C:5]([CH:7]2[CH2:9][CH2:8]2)[O:4][N:3]=1.[CH2:10]([NH2:13])[CH2:11][NH2:12]>>[CH:7]1([C:5]2[O:4][N:3]=[C:2]([NH:12][CH2:11][CH2:10][NH2:13])[N:6]=2)[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 3301EthylenediamineHCID 716688623-Chloro-5-cyclopropyl-1,2,4-oxadiazole

Product 1

HCID 89825830HCID 89825830, compound

Conditions

Temperature
125 °C

Procedure

3-Chloro-5-cyclopropyl-1,2,4-oxadiazol (72 mg, 0.5 mmol) and TEA (139 μl, 1 mmol) were dissolved in ethane-1,2-diamine (3 ml), placed in a sealed tube and heated at 125° C. for 2 hours. The mixture was cooled to room temperature and evaporated to dryness under reduced pressure and used directly in the next step MS(ESI) m/z=169.1 [M+1]+.

Workup

  1. customplaced in a sealed tube
  2. temperatureThe mixture was cooled to room temperature
  3. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-1e5fa065c0de4b8abfdd375c75addb33
Source dataset
uspto-grants-2016_04
Patent number
US09321724B2

Reaction notes

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