反应详情

温度

90 °C

2-Bromo-6-methylpyridine (36 g, 0.2 mol) was dissolved in acetic acid (700 ml), hydrogen peroxide (30%, 62 ml, 0.6 mol) was added and the mixture was stirred at 90° C. for 24 hours. After cooling to room temperature, the mixture was diluted with water (700 ml) and extracted with DCM (4×). The combined organic phases were washed with water, dried (sodium sulfate) and concentrated under reduced pressure to give 36 g of a red-brown liquid (0.19 mol, 94%) MS(APCI) m/z=188.0 [M+1]+.

1. temperatureAfter cooling to room temperature
2. extractionextracted with DCM (4×)
3. washThe combined organic phases were washed with water
4. dry with materialdried (sodium sulfate)
5. concentrationconcentrated under reduced pressure