反应详情

Benzenesulfonyl chloride (0.093 g) was added to a solution of 2-amino-6-cyclopropyl-benzonitrile (Intermediate 10, 0.07 g) in DCM (4 mL) and pyridine (0.1 mL). The mixture was stirred for 5 hours, then a further aliquot of benzenesulfonyl chloride (0.093 g) was added together with triethylamine (0.12 mL) and the mixture was stirred overnight. The reaction mixture was washed with water, and the organic solution was dried with magnesium sulfate, filtered and the filtrate was evaporated under vacuum. The residue was purified by flash chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane. The fractions containing the desired product were combined and evaporated to give the title compound as a colorless oil (0.052 g).

1. stirringthe mixture was stirred overnight
2. washThe reaction mixture was washed with water
3. dry with materialthe organic solution was dried with magnesium sulfate
4. filtrationfiltered
5. customthe filtrate was evaporated under vacuum
6. customThe residue was purified by flash chromatography on silica
7. washeluting with a mixture of ethyl acetate and cyclohexane
8. additionThe fractions containing the desired product
9. customevaporated