反应详情

2-(1-Benzyl-1H-tetrazol-5-yl)-3-methylphenylamine (Intermediate 16, 0.15 g) was dissolved in pyridine (5 mL) and benzenesulfonyl chloride (0.07 g, 0.4 mmol) was added. The mixture was stirred overnight, then diluted with ethyl acetate and washed with 1N hydrochloric acid, dried with magnesium sulfate and filtered. The filtrate was evaporated to dryness and the residue was purified by flash chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane. The fractions containing the desired product were combined and evaporated to give the title compound as a white powder (0.16 g).

1. washwashed with 1N hydrochloric acid
2. dry with materialdried with magnesium sulfate
3. filtrationfiltered
4. customThe filtrate was evaporated to dryness
5. customthe residue was purified by flash chromatography on silica
6. washeluting with a mixture of ethyl acetate and cyclohexane
7. additionThe fractions containing the desired product
8. customevaporated