反应详情

2-Bromo-6-nitrobenzonitrile (5 g) was dissolved in a solution of methanol (100 mL) and dioxane (65 mL) and heated to reflux. Iron powder (4.6 g) was added portion wise over 20 minutes and the mixture was heated at reflux for 4 hours. The mixture was allowed to cool to room temperature, filtered and the filtrate was evaporated under vacuum. The residue was triturated with water and the solid was collected by filtration to give the title compound as a light brown solid (3.8 g).

1. temperatureheated to reflux
2. temperaturethe mixture was heated
3. temperatureat reflux for 4 hours
4. filtrationfiltered
5. customthe filtrate was evaporated under vacuum
6. customThe residue was triturated with water
7. filtrationthe solid was collected by filtration