Methyl 2-amino-2-methylpropanoate → 2-{[6-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carbonyl]-amino}-2-methyl-propionic acid methyl ester

HRID 631968Notes

Reaction equation

HRID 631968 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[CH3:21][O:22][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[NH2:25]>>[CH3:21][O:22][C:23](=[O:28])[C:24]([NH:25][C:12]([C:10]1[CH:9]=[CH:8][C:7]([CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([CH3:27])[CH3:26]

Participants

3

Reactant 2

HCID 4186341Methyl 2-amino-2-methylpropanoateHCID 710874016-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acid

Product 1

HCID 710873402-{[6-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carbonyl]-amino}-2-methyl-propionic acid methyl ester

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acid and 2-methyl-alanine methyl ester as starting materials, MS (EI): m/e 377.2 [M+H]+.

Sources & evidence

ORD record
ord-e6744c87ff4b45fd9504b78e4c351106
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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