4-Aminotetrahydropyran → HCID 71105542, compound

HRID 631987Notes

Reaction equation

HRID 631987 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[O:17]1[CH2:22][CH2:21][CH:20]([NH2:23])[CH2:19][CH2:18]1>>[O:17]1[CH2:22][CH2:21][CH:20]([NH:23][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:16])[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 247301356-(3-Chlorophenyl)picolinic acid

Product 1

HCID 71105542HCID 71105542, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and tetrahydro-2H-pyran-4-amine (CAN 38041-19-9) as starting materials, MS (LC/MS): 317.1 [M+H]+.

Sources & evidence

ORD record
ord-299c68befcfd40e0bf702afc81ba442d
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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