1,1-Dimethoxyethyl(dimethyl)amine → HCID 86674739, compound

HRID 631988Notes

Reaction equation

HRID 631988 reaction equation
[NH2:1][C:2](=[S:14])[C:3]([NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([CH3:5])[CH3:4].CO[C:17](OC)([N:19]([CH3:21])[CH3:20])[CH3:18]>C(Cl)Cl>[C:9]([O:8][C:7](=[O:13])[NH:6][C:3]([CH3:5])([CH3:4])[C:2]([N:1]=[C:17]([N:19]([CH3:21])[CH3:20])[CH3:18])=[S:14])([CH3:12])([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 15186362Carbamic acid, (2-amino-1,1-dimethyl-2-thioxoethyl)-, 1,1-dimethylethyl ester

Product 1

HCID 86674739HCID 86674739, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of tert-butyl 1-amino-2-methyl-1-thioxopropan-2-ylcarbamate (Example 12 b, 0.218 g, 1 mmol) and 1,1-dimethoxy-N,N-dimethylethanamine (CAN 18871-66-4, 0.16 g, 1.2 mmol) in methylene chloride (10 mL) was stirred at room temperature for 24 h. Then it was concentrated to give crude product, which was used directly in the next step without further purification (0.28 g, 98%) as yellow oil; MS (EI): m/e 288.2 [M+H]+.

Workup

  1. concentrationThen it was concentrated
  2. customto give crude product, which
  3. customwas used directly in the next step without further purification (0.28 g, 98%) as yellow oil

Sources & evidence

ORD record
ord-156fc019b4e94d5ba01455d015a12e21
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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