反应详情

A solution of (S)-tert-butyl 2-cyclopropyl-1-(5-methyl-1,2,4-oxadiazol-3-yl)ethylcarbamate (0.5 g, 2 mmol) in sat. hydrochloric acid (10 mL) was stirred at room temperature for 1 h. Then water (20 mL) was added. The water phase was washed with ethyl acetate (2×20 mL) and adjusted with 2 M sodium hydroxide solution to pH=9˜10. It was then extracted with ethyl acetate (2×20 mL). The organic layer was washed with brine (20 mL), dried over anhydrous sodium sulfate and concentrated to give crude product as a white solid (0.25 g, 80%); MS (EI): m/e 168.2 [M+H]+.

1. washThe water phase was washed with ethyl acetate (2×20 mL)
2. extractionIt was then extracted with ethyl acetate (2×20 mL)
3. washThe organic layer was washed with brine (20 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated