(S)-alpha-(2-methylpropyl)-2-thiazolemethanamine → 6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid ((S)-3-methyl-1-thiazol-2-yl-butyl)-amide
反応式
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1.[CH3:16][CH:17]([CH3:26])[CH2:18][C@@H:19]([C:21]1[S:22][CH:23]=[CH:24][N:25]=1)[NH2:20]>>[CH3:16][CH:17]([CH3:26])[CH2:18][C@H:19]([NH:20][C:12]([C:10]1[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[C:21]1[S:22][CH:23]=[CH:24][N:25]=1参加物
3
実験手順
The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (Example 36 d) and (S)-α-(2-methylpropyl)-2-thiazolemethanamine (Example 56 d) as starting materials, MS (EI): m/e=360.2 [M+H]+.
出典と根拠
- ORDレコード
- ord-163ac065354c4338aa84c649abd29985
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09321727B2
反応ノート
読み込み中…