2-(1,2,4-Oxadiazol-3-yl)propan-2-amine → 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-methyl-1-[1,2,4]oxadiazol-3-yl-ethyl)-amide

HRID 632085Notes

Reaction equation

HRID 632085 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][C:19]([NH2:26])([C:21]1[N:25]=[CH:24][O:23][N:22]=1)[CH3:20]>>[CH3:18][C:19]([NH:26][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([C:21]1[N:25]=[CH:24][O:23][N:22]=1)[CH3:20]

Participants

3

Reactant 2

HCID 435591182-(1,2,4-Oxadiazol-3-yl)propan-2-amineHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 711055815-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-methyl-1-[1,2,4]oxadiazol-3-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and 1-methyl-1-[1,2,4]oxadiazol-3-yl-ethylamine (CAN 1153757-41-5) as starting materials, MS (LC/MS): 343.1 (M+H).

Sources & evidence

ORD record
ord-427e5b7f623d4b0b8dabcecec05e2b62
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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