5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid → 5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide

HRID 632128Notes

Reaction equation

HRID 632128 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]([OH:17])=O)=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=1.[CH3:18][C:19]([CH3:26])([C:21]1[O:22][CH:23]=[CH:24][N:25]=1)[NH2:20]>>[CH3:18][C:19]([NH:20][C:15]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)[N:6]=1)=[O:17])([C:21]1[O:22][CH:23]=[CH:24][N:25]=1)[CH3:26]

Participants

3

Reactant 2

HCID 710876195-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acidHCID 82418817alpha,alpha-Dimethyl-2-oxazolemethanamine

Product 1

HCID 711055945-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (Example 58 c) and α,α-dimethyl-2-oxazolemethanamine (CAN 1211519-76-4) as starting materials, MS (EI): m/e=376.0 [M+H]+.

Sources & evidence

ORD record
ord-88f9a73943914862968b817cfb3338b9
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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