Cyclopropylboronic acid → 5-Cyclopropyl-6-(pyridin-2-ylmethoxy)-pyridine-2-carboxylic acid

HRID 632252Notes

Reaction equation

Br[C:2]1[CH:3]=[CH:4][C:5]([C:16]([OH:18])=[O:17])=[N:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.[CH:19]1(B(O)O)[CH2:21][CH2:20]1>>[CH:19]1([C:2]2[CH:3]=[CH:4][C:5]([C:16]([OH:18])=[O:17])=[N:6][C:7]=2[O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)[CH2:21][CH2:20]1

Participants

Reactant 2

HCID 2760897Cyclopropylboronic acid

HCID 71087727HCID 71087727, compound

Product 1

HCID 710877855-Cyclopropyl-6-(pyridin-2-ylmethoxy)-pyridine-2-carboxylic acid

Procedure

The title compound was synthesized in analogy to Example 42 a, using 5-bromo-6-(pyridin-2-ylmethoxy)-pyridine-2-carboxylic acid and cyclopropylboronic acid (CAN 411235-57-9) as starting materials, LC-MS (UV peak area/ESI) 100%, 271.1081 (M+H)+.

Sources & evidence

ORD record: ord-f1f5f1aaf46d4e87b2152b773c826d02
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321727B2

Reaction notes

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