反应详情

A 4M solution of HCl in dioxane (4.68 mL, 18.7 mmol) was added to a solution of (S)-tert-butyl 3-cyclopropyl-1-(dimethylamino)-1-oxopropan-2-ylcarbamate (1.2 g, 4.68 mmol) in ethanol (10 mL). After 16 h stirring at ambient temperature the solvent was removed under reduced pressure. The remaining solid was digerated with diethyl ether (10 mL), filtered off, washed with diethyl ether (3×5 mL) and dried for 3 h in vacuo at 40° C. to give the title compound as off-white solid (820 mg, 91%). MS (EI): m/e=157.1 [M+H]+.

1. customwas removed under reduced pressure
2. filtrationfiltered off
3. washwashed with diethyl ether (3×5 mL)
4. customdried for 3 h in vacuo at 40° C.