Dimethylamine, hydrochloride → HCID 71105678, compound

HRID 632319Notes

Reaction equation

[CH2:1]([C:3]([NH:9][C:10](=[O:29])[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[C:13]([O:21][CH2:22][CH:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:12]=1)([CH2:7][CH3:8])[C:4]([OH:6])=O)[CH3:2].Cl.[CH3:31][NH:32][CH3:33]>>[CH3:31][N:32]([CH3:33])[C:4]([C:3]([NH:9][C:10]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[C:13]([O:21][CH2:22][CH:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[N:12]=1)=[O:29])([CH2:7][CH3:8])[CH2:1][CH3:2])=[O:6]

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 71087372HCID 71087372, compound

Product 1

HCID 71105678HCID 71105678, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 2-ethyl-2-(6-((tetrahydro-2H-pyran-4-yl)methoxy)-5-(trifluoromethyl)picolinamido)butanoic acid (Example 253 a) and dimethylamine hydrochloride as starting materials. MS (EI): m/e=463.4 [M+NH4]+.

Sources & evidence

ORD record: ord-089758a658fd40faa9359db717253095
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321727B2

Reaction notes

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