Hydrochloric Acid → HCID 86674783, compound

HRID 632354Notes

Reaction equation

HRID 632354 reaction equation
C(OC(=O)[NH:7][C:8]([C:11]1[N:15]=[C:14]([NH2:16])[O:13][N:12]=1)([CH3:10])[CH3:9])(C)(C)C.[ClH:18].O1CCOCC1>C(O)C>[ClH:18].[NH2:7][C:8]([C:11]1[N:15]=[C:14]([NH2:16])[O:13][N:12]=1)([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71087515HCID 71087515, compound

Product 1

HCID 86674783HCID 86674783, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of [1-(5-amino-[1,2,4]oxadiazol-3-yl)-1-methyl-ethyl]carbamic acid tert-butyl ester (1.6 g, 6.6 mmol) in ethanol (30 mL) was added HCl in dioxane (4 M, 6.6 ml, 26.4 mmol) and the reaction mixture was stirred 16 hours at room temperature. The reaction mixture was concentrated in vacuo and dried by applying high vacuum at 40° C. for 4 hours to give the title compound as off-white solid (1.2 g, quant.); LC-MS (UV peak area/ESI) 99.9%, 143.0927 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customdried
  3. customat 40° C.
  4. customfor 4 hours

Sources & evidence

ORD record
ord-8f3534f0e59c4e7db71da8de81df4ef9
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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