HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-amino-N,4,4-trimethyl-pentanamide → 5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-amino-N,4,4-trimethyl-pentanamide | HCID 57635521 | — |
| Reactant | 6-(2,2,3,3,3-Pentafluoro-propoxy)-pyridine-2-carboxylic acid | HCID 86674786 | — |
| Reactant | 5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid | HCID 86674787 | — |
| Product | 5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide | HCID 86674789 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using the mixture of 6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid and 5-cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid (Example 297b) and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials, the product was isolated by preparative HPLC; LC-MS (UV peak area/ESI) 100%, 452.1962 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-e5639b9e40434a30b2079e77f8a4dec9 |
| Source note | uspto-grants-2016_04 |