Hydrochloric Acid → HCID 86674792, compound

HRID 632371Notes

Reaction equation

HRID 632371 reaction equation
C(OC(=O)[NH:7][C:8]([C:11]1[O:15][N:14]=[C:13]([NH2:16])[N:12]=1)([CH3:10])[CH3:9])(C)(C)C.[ClH:18].O1CCOCC1>C(O)C>[ClH:18].[NH2:7][C:8]([C:11]1[O:15][N:14]=[C:13]([NH2:16])[N:12]=1)([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71087789HCID 71087789, compound

Product 1

HCID 86674792HCID 86674792, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of [1-(3-amino-[1,2,4]oxadiazol-5-yl)-1-methyl-ethyl]carbamic acid tert-butyl ester (100 mg, 0.41 mmol) in ethanol (2 mL) was added HCl in dioxane (4 M, 0.41 ml, 1.65 mmol) and the reaction mixture was stirred 16 hours at room temperature. The reaction mixture was concentrated in vacuo and dried by applying high vacuum at 40° C. for 4 hours to give the title compound as white solid (75 mg, quant.); LC-MS (UV peak area/ESI) nd, 143.0928 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customdried
  3. customat 40° C.
  4. customfor 4 hours

Sources & evidence

ORD record
ord-8bf871ae4b514c618034c1c77113c1d5
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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