Lithium Hydroxide → (S)-2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-3,3-dimethylbutanoic acid

反応式

[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([NH:14][C@@H:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([O:18]C)=[O:17])=[O:13])[CH:9]=[CH:8][C:7]=2[N:24]2[CH2:27][C:26]([F:29])([F:28])[CH2:25]2)[CH2:3][CH2:2]1.[OH-].[Li+]>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([NH:14][C@@H:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([OH:18])=[O:17])=[O:13])[CH:9]=[CH:8][C:7]=2[N:24]2[CH2:27][C:26]([F:28])([F:29])[CH2:25]2)[CH2:3][CH2:2]1

参加物

反応物 2

HCID 3939Lithium Hydroxide

HCID 71087806(S)-Methyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-3,3-dimethylbutanoate

生成物 1

HCID 71087773(S)-2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-3,3-dimethylbutanoic acid

実験手順

In analogy to the procedure described in Example 5 c), (S)-methyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-3,3-dimethylbutanoate was saponified with lithium hydroxide to obtain the title compound. MS (EI): m/e=396.1 [M−H]−.

出典と根拠

ORDレコード: ord-3f47caaa4c8644ce877f8cf4f7bdda2e
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09321727B2

反応ノート

読み込み中…