反应详情

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and 3-methyl-1-(pyridazin-3-yl)butan-1-amine (Example 321 a) as starting materials. The product was isolated by chiral chromatography on Reprosil Chiral NR using a mixture of heptane, ethanol and 2-propanol as eluent. The (−)-enantiomer was isolated. MS (EI): m/e=432.5 [M+H]+.

1. customThe product was isolated by chiral chromatography on Reprosil Chiral NR
2. customThe (−)-enantiomer was isolated