反应详情

温度

50 °C

To a magnetically stirred mixture of 2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(2,2,2-trifluoroethoxy)pyridine (775 mg, 2.033 mmol) and ammonium chloride (326 mg, 6.10 mmol) in MeOH (6.776 mL) was added sodium azide (396 mg, 6.10 mmol) in a 20 mL vial under a N2 atmosphere. The reaction mixture was stirred at 50° C. for 16 h. The reaction was cooled to rt, then volatiles were removed under a gentle stream of N2. Et2O was added to the resulting residue and stirred rapidly for 5 min, then filtered to remove solids. The volatiles were removed by rotary evaporation and the resulting oil was carried on without further purification.

1. temperatureThe reaction was cooled to rt
2. customvolatiles were removed under a gentle stream of N2
3. additionEt2O was added to the resulting residue
4. stirringstirred rapidly for 5 min
5. filtrationfiltered
6. customto remove solids
7. customThe volatiles were removed by rotary evaporation
8. customthe resulting oil was carried on without further purification