反应详情

To a stirred solution of 3-bromo-4-hydroxybenzoic acid (Commercial eg Aldrich) (2.0 g), EDC (2.65 g), HOBT (1.41 g) and TEA (6.2 ml) in DCM (60 ml) was added methylamine hydrochloride (1.87 g). This was stirred at 25-30 C. for 16 h. The solvent was removed under reduced pressure. The residue was dissolved in water and extracted with ethyl acetate. The organics were dried (sodium sulphate) and concentrated in vacuo to yield the title compound, 0.57 g

1. customThe solvent was removed under reduced pressure
2. dissolutionThe residue was dissolved in water
3. extractionextracted with ethyl acetate
4. dry with materialThe organics were dried (sodium sulphate)
5. concentrationconcentrated in vacuo