反应详情

To a stirred solution of 3,4-bis(methyloxy)phenol (Commercial eg Alfa Aesar) (1.0 g) and DIPEA (2.28 ml) in DCM (15 ml) was added chloromethyl methyl ether (0.74 ml) at 0 C. After stirring at 25-30 C. for 17 h, the reaction was washed with dilute hydrochloric acid and saturated aqueous sodium bicarbonate. This was dried over sodium sulphate and purified through silica eluting with 0-5% ethyl acetate in hexane, to give the title compound, 0.80 g

1. washthe reaction was washed with dilute hydrochloric acid and saturated aqueous sodium bicarbonate
2. dry with materialThis was dried over sodium sulphate
3. custompurified through silica eluting with 0-5% ethyl acetate in hexane