HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 632767Generated: October 29, 2026
Itaconic acid → 1-(4-bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid
https://huagongshe.com/reaction/632767
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Itaconic acid | HCID 811 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-bromo-1-methyl-1H-pyrazol-3-amine | HCID 2735283 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(4-bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid | HCID 118061881 | — |
Reaction Steps
To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (312 mg) in a mixed solvent of water (2.0 mL) and toluene (2.0 mL) was added itaconic acid (245 mg). The reaction mixture was stirred at 120° C. for 5 hr, and the solvent was evaporated under reduced pressure. The residue was used for the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09321757B2 |
|---|
| Source dataset | uspto-grants-2016_04 |
|---|
| ORD ID | ord-e2c31f9bde1545b2bcfda8189e8bfbc2 |
|---|
| Source note | uspto-grants-2016_04 |
|---|
