Itaconic acid → 1-(4-bromo-1-methyl-1H-pyrazol-3-yl)-5-oxopyrrolidine-3-carboxylic acid
Reaction equation
[Br:1][C:2]1[C:3]([NH2:8])=[N:4][N:5]([CH3:7])[CH:6]=1.O.[C:10]([OH:18])(=[O:17])[C:11]([CH2:13][C:14](O)=[O:15])=[CH2:12]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:3]([N:8]2[C:14](=[O:15])[CH2:13][CH:11]([C:10]([OH:18])=[O:17])[CH2:12]2)=[N:4][N:5]([CH3:7])[CH:6]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (312 mg) in a mixed solvent of water (2.0 mL) and toluene (2.0 mL) was added itaconic acid (245 mg). The reaction mixture was stirred at 120° C. for 5 hr, and the solvent was evaporated under reduced pressure. The residue was used for the next step without purification.
Workup
- customthe solvent was evaporated under reduced pressure
- customThe residue was used for the next step without purification
Sources & evidence
- ORD record
- ord-e2c31f9bde1545b2bcfda8189e8bfbc2
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321757B2
Reaction notes
Loading…